Early-onset childhood atopic dermatitis is related to NLRP2 repression

Loreen Thürmann; Konrad Grützmann; Matthias Klös; Matthias Bieg; Marcus Winter; Tobias Polte; Tobias Bauer; Matthias Schick; Melanie Bewerunge-Hudler; Stefan Röder; Mario Bauer; Dirk K Wissenbach; Ulrich Sack; Dieter Weichenhan; Oliver Mücke; Christoph Plass; Michael Borte; Martin von Bergen; Irina Lehmann; Roland Eils; Saskia Trump

doi:10.1016/j.jaci.2017.11.018

Early-onset childhood atopic dermatitis is related to NLRP2 repression

J Allergy Clin Immunol. 2018 Apr;141(4):1482-1485.e16. doi: 10.1016/j.jaci.2017.11.018. Epub 2017 Dec 9.

Authors

Loreen Thürmann¹, Konrad Grützmann², Matthias Klös¹, Matthias Bieg³, Marcus Winter¹, Tobias Polte¹, Tobias Bauer⁴, Matthias Schick⁵, Melanie Bewerunge-Hudler⁵, Stefan Röder¹, Mario Bauer¹, Dirk K Wissenbach⁶, Ulrich Sack⁷, Dieter Weichenhan⁸, Oliver Mücke⁸, Christoph Plass⁸, Michael Borte⁹, Martin von Bergen¹⁰, Irina Lehmann¹¹, Roland Eils¹², Saskia Trump¹³

Affiliations

¹ Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany.
² Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany; Center for Molecular Tumor Diagnostics at the National Center for Tumor Diseases, partner site Dresden, Dresden, Germany.
³ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁶ Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany; Institute of Forensic Medicine, University Hospital Jena, Jena, Germany.
⁷ Institute of Clinical Immunology, University Hospital Leipzig, Leipzig, Germany.
⁸ Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁹ Municipal Hospital "St. Georg" Children's Hospital, Leipzig, Germany.
¹⁰ Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany; Department of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany.
¹¹ Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany. Electronic address: [email protected].
¹² Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg, German Center for Lung Research, University of Heidelberg, Heidelberg, Germany.
¹³ Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany. Electronic address: [email protected].

PMID: 29233739
DOI: 10.1016/j.jaci.2017.11.018

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Adaptor Proteins, Signal Transducing / immunology
Apoptosis Regulatory Proteins
Child
Child, Preschool
Dermatitis, Atopic / genetics*
Dermatitis, Atopic / immunology
Eczema / genetics
Eczema / immunology
Female
Humans
Immunity, Innate / genetics
Immunity, Innate / immunology
Infant
Male
Polymorphism, Single Nucleotide / genetics
Risk Factors

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
NLRP2 protein, human