Alcohol, stem cells and cancer

Shoujun Gu; Bao-Ngoc Nguyen; Shuyun Rao; Shulin Li; Kirti Shetty; Asif Rashid; Vivek Shukla; Chu-Xia Deng; Lopa Mishra; Bibhuti Mishra

doi:10.18632/genesandcancer.156

Alcohol, stem cells and cancer

Genes Cancer. 2017 Sep;8(9-10):695-700. doi: 10.18632/genesandcancer.156.

Authors

Shoujun Gu¹, Bao-Ngoc Nguyen¹, Shuyun Rao¹, Shulin Li², Kirti Shetty³, Asif Rashid⁴, Vivek Shukla⁵, Chu-Xia Deng^{1

6}, Lopa Mishra^{1

7}, Bibhuti Mishra¹

Affiliations

¹ Department of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA.
² Departments of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
³ Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ Departments of Gastroenterology and Liver Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁵ Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.
⁶ Faculty of Health Sciences, University of Macau, Macau SAR, China.
⁷ Surgical Service, Veterans Affairs Medicale Center, Washington DC, USA.

Abstract

Dosage, gender, and genetic susceptibility to the effects of alcohol remained only partially elucidated. In this review, we summarize the current knowledge of the mechanisms underlying the role of alcohol in liver and gastrointestinal cancers. In addition, two recent pathways- DNA repair and TGF-β signaling which provide new insights into alcohol in the regulation of cancers and stem cells are also discussed here.

Keywords: DNA repair; TGF-β; alcohol; cancer; stem cells.

Publication types

Review

Abstract

Publication types

Grants and funding