Organocatalytic C(sp3)-H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]azepines

Org Lett. 2018 Jan 5;20(1):138-141. doi: 10.1021/acs.orglett.7b03492. Epub 2017 Dec 14.

Abstract

Carbocation-initiated cascade [1,5]-hydride transfer/cyclization and dimerization reactions were developed to synthesize dihydrodibenzo[b,e]azepine and octahydrodipyrroloquinoline derivatives in high yields. These redox-neutral C(sp3)-H functionalization-involving cascade reactions feature transition-metal-free, high atom- and step-economy, and environmental friendliness with water as the sole byproduct.

Publication types

  • Research Support, Non-U.S. Gov't