The Effect of Antiretroviral Stock-Outs on Medication Adherence Among Patients Living With HIV in Ghana: A Qualitative Study

J Assoc Nurses AIDS Care. 2018 Mar-Apr;29(2):231-240. doi: 10.1016/j.jana.2017.09.014. Epub 2017 Oct 9.

Abstract

Stock-outs of medications for antiretroviral therapy have been reported as a significant barrier to HIV care in sub-Saharan Africa, but patient responses to these shortages have not been fully described. The aim of our study was to employ qualitative methods to examine the role of medication stock-outs in contributing to treatment interruption among a sample of patients already engaged in care for HIV at Komfo Anokye Teaching Hospital in Kumasi, Ghana. We found that medication stock-outs presented a number of challenges to adherence for patients undergoing HIV treatment. Often, patients interrupted treatment until the stock-out ended. Those who did not interrupt treatment during stock-outs coped with shortages by stockpiling old medication or experienced clinic-initiated changes to their treatment regimens. Particularly in areas lacking the resources to monitor viral load or viral genotype, viral resistance could develop due to frequent unstructured treatment interruptions as a result of stock-outs.

Keywords: Ghana; antiretroviral therapy; medication adherence; treatment interruption.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Ambulatory Care Facilities
  • Anti-HIV Agents / economics
  • Anti-HIV Agents / supply & distribution*
  • Anti-HIV Agents / therapeutic use
  • Anti-Retroviral Agents / economics
  • Anti-Retroviral Agents / supply & distribution*
  • Anti-Retroviral Agents / therapeutic use*
  • Drug Resistance, Viral / genetics
  • Female
  • Ghana
  • HIV Infections / drug therapy*
  • HIV Infections / economics
  • HIV-1 / drug effects
  • HIV-1 / genetics
  • Humans
  • Male
  • Medication Adherence*
  • Middle Aged
  • Qualitative Research
  • Socioeconomic Factors
  • Treatment Outcome
  • Viral Load / drug effects*

Substances

  • Anti-HIV Agents
  • Anti-Retroviral Agents