Sweet! Helicobacter Sugar Calms Intestinal Macrophages

Calum C Bain; Marika C Kullberg

doi:10.1016/j.chom.2017.11.014

Sweet! Helicobacter Sugar Calms Intestinal Macrophages

Cell Host Microbe. 2017 Dec 13;22(6):719-721. doi: 10.1016/j.chom.2017.11.014.

Authors

Calum C Bain¹, Marika C Kullberg²

Affiliations

¹ The University of Edinburgh/MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Electronic address: [email protected].
² Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, Wentworth Way, Heslington, York YO10 5DD, UK. Electronic address: [email protected].

PMID: 29241034
DOI: 10.1016/j.chom.2017.11.014

Abstract

In the absence of IL-10, Helicobacter hepaticus (Hh) induces colitis. In this issue of Cell Host & Microbe, Danne et al. (2017) report that Hh produces a polysaccharide that induces an anti-inflammatory response in macrophages, providing a potential clue as to why this bacterium is normally tolerated by the immune system.

Publication types

Comment

MeSH terms

Colitis / immunology
Helicobacter / immunology*
Helicobacter Infections / immunology
Interleukin-10 / immunology
Macrophages / immunology
Sugars*

Substances

Sugars
Interleukin-10