Case: A 66-year-old Caucasian man with Klippel-Trenaunay-Weber syndrome (KTWS) presented with chronic changes related to the KTWS, along with worsening pain and motion associated with residual damage from an episode of spontaneous septic arthritis that occurred 1 year prior. He underwent total joint arthroplasty with a rotating hinged knee implant.
Conclusion: Arthroplasty is a treatment option for patients with KTWS; however, there are risks that must be considered. This case report outlines the management of a patient with KTWS and a history of septic arthritis.