Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients

K Walkiewicz; E Nowakowska-Zajdel; J Strzelczyk; S Dzięgielewska-Gęsiak; M Muc-Wierzgoń

Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients

J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):929-934.

Authors

K Walkiewicz¹, E Nowakowska-Zajdel², J Strzelczyk³, S Dzięgielewska-Gęsiak¹, M Muc-Wierzgoń¹

Affiliations

¹ Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland.
² Department of Nutrition Related Disease Prevention, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland.
³ Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

PMID: 29254295

Abstract

Colorectal cancer is the third most common cancer in the world. Our study analyzed the potential significance of serum levels of selected adamalysines (ADAM10, ADAM12, ADAM17, ADAM28) in colorectal cancer patients. The study was performed on a group of 85 colorectal cancer patients (48 men, 37 women). Serum protein concentrations were measured by ELISA. The ADAMs serum level changes were analyzed according to selected clinical parameters (BMI, sex, age, clinical stage of disease). The following ranges of concentration of analyzed proteins were obtained: ADAM10 min=1.7, max=321.8 [ng/ml]; ADAM12 min=0.6, max=26.7 [ng/ml]; ADAM17 min=0.4, max=9.8 [ng/ml]; ADAM28 min=17.1, max=1545.8 [ng/ml]. In addition, it was stated that there is a relationship between the serum level of ADAM28 and the degree of the clinical stage (p less than 0.04). The obtained results could be the starting point for further research into the role of adamalysines in the development of colorectal cancer, as well as the potential predictive and prognostic value of these proteins.

MeSH terms

ADAM Proteins / blood
ADAM Proteins / genetics*
ADAM10 Protein / blood
ADAM10 Protein / genetics
ADAM12 Protein / blood
ADAM12 Protein / genetics
ADAM17 Protein / blood
ADAM17 Protein / genetics
Adenocarcinoma / blood
Adenocarcinoma / diagnosis
Adenocarcinoma / genetics*
Adenocarcinoma / pathology
Adult
Age Factors
Aged
Aged, 80 and over
Amyloid Precursor Protein Secretases / blood
Amyloid Precursor Protein Secretases / genetics
Biomarkers, Tumor / blood
Biomarkers, Tumor / genetics*
Body Mass Index
Colon / metabolism*
Colon / pathology
Colorectal Neoplasms / blood
Colorectal Neoplasms / diagnosis
Colorectal Neoplasms / genetics*
Colorectal Neoplasms / pathology
Female
Gene Expression Regulation, Neoplastic*
Humans
Male
Membrane Proteins / blood
Membrane Proteins / genetics
Middle Aged
Neoplasm Staging
Sex Factors

Substances

Biomarkers, Tumor
Membrane Proteins
Amyloid Precursor Protein Secretases
ADAM Proteins
ADAM12 Protein
ADAM12 protein, human
ADAM28 protein, human
ADAM10 Protein
ADAM10 protein, human
ADAM17 Protein
ADAM17 protein, human