1 School of Public Health, Xinxiang Medical University, the Second Affiliated Hospital, Xinxiang, ChinaSchool of Public Health, Xinxiang Medical University, Xinxiang, Chin;School of Pharmacy, Xinxiang Medical University, Xinxiang, China;Department of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China;School of Pharmacy, Xinxiang Medical University, Xinxiang, China;The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;McLean Hospital & Harvard Medical School, Boston, MA;School of Pharmacy, Xinxiang Medical University, Xinxiang, China [email protected];Xinxiang Medical University, the Second Affiliated Hospital, Xinxiang, China [email protected] Medical University, the Second Affiliated Hospital, Xinxiang, China.