Different clonal dynamics of chronic myeloid leukaemia between bone marrow and the central nervous system

Miho Ogawa; Kazuaki Yokoyama; Mitsuhito Hirano; Koji Jimbo; Kiyosumi Ochi; Toyotaka Kawamata; Nobuhiro Ohno; Eigo Shimizu; Nozomi Yokoyama; Rui Yamaguchi; Seiya Imoto; Kaoru Uchimaru; Naoto Takahashi; Satoru Miyano; Yoichi Imai; Arinobu Tojo

doi:10.1111/bjh.15065

Different clonal dynamics of chronic myeloid leukaemia between bone marrow and the central nervous system

Br J Haematol. 2018 Dec;183(5):842-845. doi: 10.1111/bjh.15065. Epub 2017 Dec 19.

Authors

Miho Ogawa¹, Kazuaki Yokoyama¹, Mitsuhito Hirano¹, Koji Jimbo¹, Kiyosumi Ochi¹, Toyotaka Kawamata¹, Nobuhiro Ohno¹, Eigo Shimizu², Nozomi Yokoyama³, Rui Yamaguchi², Seiya Imoto⁴, Kaoru Uchimaru^{1

5}, Naoto Takahashi⁶, Satoru Miyano², Yoichi Imai¹, Arinobu Tojo^{1

7}

Affiliations

¹ Department of Haematology/Oncology, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
² Laboratory of DNA Information Analysis, Human Genome Centre, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
³ Department of Applied Genomics, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
⁴ Division of Health Medical Data Science, Health Intelligence Centre, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
⁵ Laboratory of Tumour Cell Biology, Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.
⁶ Department of Haematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
⁷ Division of Molecular Therapy, Advanced Clinical Research Centre, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

PMID: 29265350
DOI: 10.1111/bjh.15065

No abstract available

Keywords: BCR-ABL1 mutation; chronic myeloid leukaemia; deep sequencing; in vivo bioavailability of nilotinib; isolated central nervous system relapse.

Publication types

Case Reports
Letter

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Blast Crisis
Bone Marrow Neoplasms / drug therapy
Central Nervous System Neoplasms / drug therapy
Dasatinib / administration & dosage
Drug Administration Schedule
Drug Substitution
Fatal Outcome
Female
Humans
Imatinib Mesylate / therapeutic use
Imidazoles / administration & dosage
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
Middle Aged
Pyridazines / administration & dosage
Pyrimidines / administration & dosage
Recurrence

Substances

Imidazoles
Pyridazines
Pyrimidines
ponatinib
Imatinib Mesylate
nilotinib
Dasatinib