Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon

Trends Parasitol. 2018 Mar;34(3):178-179. doi: 10.1016/j.pt.2017.12.002. Epub 2017 Dec 20.

Abstract

Decades after the last new chemical entity was added to the pharmacopeia for human African trypanosomiasis (or sleeping sickness), orally dosed fexinidazole stands poised to replace the current treatment regimen for Trypanosoma brucei gambiense infections, following a positive Phase 2/3 clinical trial.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Clinical Trials as Topic
  • Drug Approval
  • Humans
  • Nitroimidazoles / therapeutic use*
  • Trypanocidal Agents / therapeutic use*
  • Trypanosoma brucei gambiense*
  • Trypanosomiasis, African / drug therapy*

Substances

  • Nitroimidazoles
  • Trypanocidal Agents
  • fexinidazole