RNA splicing and its connection with other regulatory layers in somatic cell reprogramming

Mihaela Zavolan; Alexander Kanitz

doi:10.1016/j.ceb.2017.12.002

RNA splicing and its connection with other regulatory layers in somatic cell reprogramming

Curr Opin Cell Biol. 2018 Jun:52:8-13. doi: 10.1016/j.ceb.2017.12.002. Epub 2017 Dec 21.

Authors

Mihaela Zavolan¹, Alexander Kanitz²

Affiliations

¹ RNA Regulatory Networks, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland. Electronic address: [email protected].
² RNA Regulatory Networks, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.

PMID: 29275148
DOI: 10.1016/j.ceb.2017.12.002

Abstract

Understanding how cell identity is established and maintained is one of the most exciting challenges of molecular biology today. Recent work has added a conserved layer of RNA splicing and other post-transcriptional regulatory processes to the transcriptional and epigenetic networks already known to cooperate in the establishment and maintenance of cell identity. Here we summarize these findings, highlighting specifically the multitude of splicing factors that can modulate the efficiency of somatic cell reprogramming. Distinct patterns of gene expression dynamics of these factors during reprogramming suggest that further improvements in efficiency could be obtained through optimal timing of overexpression or knockdown of individual regulators.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cellular Reprogramming / genetics*
Gene Expression Regulation / genetics*
Humans
RNA Splicing / genetics*