Role of Stem Cells in Pathophysiology and Therapy of Spondyloarthropathies-New Therapeutic Possibilities?

Magdalena Krajewska-Włodarczyk; Agnieszka Owczarczyk-Saczonek; Waldemar Placek; Adam Osowski; Piotr Engelgardt; Joanna Wojtkiewicz

doi:10.3390/ijms19010080

Role of Stem Cells in Pathophysiology and Therapy of Spondyloarthropathies-New Therapeutic Possibilities?

Int J Mol Sci. 2017 Dec 28;19(1):80. doi: 10.3390/ijms19010080.

Authors

Magdalena Krajewska-Włodarczyk^{1

2}, Agnieszka Owczarczyk-Saczonek³, Waldemar Placek⁴, Adam Osowski⁵, Piotr Engelgardt⁶, Joanna Wojtkiewicz^{7

8

9}

Affiliations

¹ Department of Rheumatology, Municipal Hospital in Olsztyn, 10-900 Olsztyn, Poland. [email protected].
² Department of Pathophysiology, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland. [email protected].
³ Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland. [email protected].
⁴ Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland. [email protected].
⁵ Department of Pathophysiology, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland. [email protected].
⁶ Department of Forensic Medicine, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland. [email protected].
⁷ Department of Pathophysiology, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland. [email protected].
⁸ Laboratory for Regenerative Medicine, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland. [email protected].
⁹ Foundation for Nerve Cell Regeneration, University of Warmia and Mazury in Olsztyn, 10-900 Olsztyn, Poland. [email protected].

Abstract

Considerable progress has been made recently in understanding the complex pathogenesis and treatment of spondyloarthropathies (SpA). Currently, along with traditional disease modifying anti-rheumatic drugs (DMARDs), TNF-α, IL-12/23 and IL-17 are available for treatment of such diseases as ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Although they adequately control inflammatory symptoms, they do not affect the abnormal bone formation processes associated with SpA. However, the traditional therapeutic approach does not cover the regenerative treatment of damaged tissues. In this regards, stem cells may offer a promising, safe and effective therapeutic option. The aim of this paper is to present the role of mesenchymal stromal cells (MSC) in pathogenesis of SpA and to highlight the opportunities for using stem cells in regenerative processes and in the treatment of inflammatory changes in articular structures.

Keywords: inflammation; mesenchymal stem cells; spondyloarthropathies.

Publication types

Review

MeSH terms

Antirheumatic Agents / therapeutic use*
Cartilage, Articular / drug effects
Cartilage, Articular / immunology
Cartilage, Articular / pathology
Dendritic Cells / drug effects
Dendritic Cells / immunology
Dendritic Cells / pathology
Gene Expression Regulation / drug effects*
Gene Expression Regulation / immunology
Humans
Interleukin-12 / genetics
Interleukin-12 / immunology
Interleukin-17 / genetics
Interleukin-17 / immunology
Macrophages / drug effects
Macrophages / immunology
Macrophages / pathology
Mesenchymal Stem Cells / cytology*
Mesenchymal Stem Cells / immunology
Monocytes / drug effects
Monocytes / immunology
Monocytes / pathology
Neutrophils / drug effects
Neutrophils / immunology
Neutrophils / pathology
Ossification, Heterotopic / genetics
Ossification, Heterotopic / immunology
Ossification, Heterotopic / pathology
Ossification, Heterotopic / prevention & control*
Spondylarthropathies / genetics
Spondylarthropathies / immunology
Spondylarthropathies / pathology
Spondylarthropathies / therapy*
Stem Cell Transplantation / methods*
Toll-Like Receptors / genetics
Toll-Like Receptors / immunology
Tumor Necrosis Factor-alpha / genetics
Tumor Necrosis Factor-alpha / immunology

Substances

Antirheumatic Agents
Interleukin-17
Toll-Like Receptors
Tumor Necrosis Factor-alpha
Interleukin-12