Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents

Org Lett. 2018 Jan 19;20(2):337-340. doi: 10.1021/acs.orglett.7b03548. Epub 2017 Dec 28.

Abstract

The purpose of this letter is to document the use of protected chloroethyl and chloropropyl amines as conformationally unrestricted ambiphilic reagents that undergo annulation reactions with Michael acceptors. This reaction is wide in scope and utilizes reagents that are commercially available, inexpensive, and stable. Furthermore, this reaction is easy to execute and proceeds rapidly.

Publication types

  • Research Support, Non-U.S. Gov't