Lung Cancer with Concomitant Double Gene Mutation

Tao Fan; Xiu-Li Liu; Jun Zhou; Ying-Jie Song; Hong Yang; Ya-Nan Wei

doi:10.29271/jcpsp.2018.01.72

Lung Cancer with Concomitant Double Gene Mutation

J Coll Physicians Surg Pak. 2018 Jan;28(1):72-73. doi: 10.29271/jcpsp.2018.01.72.

Authors

Tao Fan¹, Xiu-Li Liu¹, Jun Zhou¹, Ying-Jie Song², Hong Yang¹, Ya-Nan Wei¹

Affiliations

¹ Department of Oncology, Three Gorges University People's Hospital, the First People's Hospital of Yichang, Xiling District, Yichang City, Hubei-443000, China.
² Department of General Surgery, Three Gorges University People's Hospital, the First People's Hospital of Yichang, Xiling District, Yichang City, Hubei-443000, China.

PMID: 29290199
DOI: 10.29271/jcpsp.2018.01.72

Abstract

A patient presenting with concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocation is very rare. We report a non-small cell lung cancer (NSCLC) patient with concomitant EGFR (exon 19-del) mutation and ALK rearrangement. The positron emission tomography-computed tomography (PET-CT) scan revealed a highly metabolic mass lesion in the left lower lobe, measured 5.0 cm in the largest dimension in the S6 segment. Transbronchial lung biopsy (TBLB) showed the pathological diagnosis of invasive adenocarcinoma. Thus, the patient underwent left lower lobectomy and hilar-mediastina lymph node dissection (pT2N0M0). The tumor harbor an ALK (D5F3 +) rearrangement and EGFR (exon 19-del) mutation. The patient initially received four cycles of chemotherapy (pemetrexed and carboplatin), and achieved partial response (PR).

MeSH terms

Adenocarcinoma / diagnostic imaging*
Adenocarcinoma / drug therapy
Adenocarcinoma / genetics*
Adenocarcinoma / pathology
Anaplastic Lymphoma Kinase
Antibodies, Monoclonal / therapeutic use
Biopsy
Carcinoma, Non-Small-Cell Lung / diagnostic imaging*
Carcinoma, Non-Small-Cell Lung / drug therapy
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / pathology
Crizotinib
Crown Ethers / therapeutic use
ErbB Receptors / genetics*
Female
Humans
Lung Neoplasms / diagnostic imaging*
Lung Neoplasms / drug therapy
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
Molecular Targeted Therapy*
Mutation
Neoplasm Staging
Nivolumab
Pemetrexed / therapeutic use
Positron Emission Tomography Computed Tomography
Pyrazoles / therapeutic use
Pyridines / therapeutic use
Quinazolines / therapeutic use
Receptor Protein-Tyrosine Kinases / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Treatment Outcome

Substances

Antibodies, Monoclonal
Crown Ethers
Pyrazoles
Pyridines
Quinazolines
Pemetrexed
Nivolumab
Crizotinib
icotinib
ALK protein, human
Anaplastic Lymphoma Kinase
ErbB Receptors
Receptor Protein-Tyrosine Kinases