Yttrium-90-Ibritumomab Tiuxetan (Zevalin®) is used in the treatment of non- Hodgkin's lymphoma. Extravasation is an iatrogenic complication that is fortunately rare. However, the treatment of this complication is often complex due to the risk of extensive skin necrosis and unpredictable evolution of localized irradiation. This vesicant drug requires emergency management when extravasation occured. Radiations burns have specificities. Therefore, wound coverage involves specific plastic surgical techniques. Here, we report the case of a man presenting a chronic and extensive skin necrosis of upper arm treated with an antero-lateral thigh free flap. Moreover, we compare our experience of Zevalin® extravasation management to other past publications and propose recommendations to prevent this unacceptable complication.
Keywords: Antero-lateral thigh free flap; Anticorps monoclonal; Complication iatrogénique; Extravasation; Iatrogenic complication; Ibritumomab tiuxetan marqué à l’Yttrium 90; Ibritumomab tiuxetan-yttrium 90; Irradiation aigue localisée; Lambeau libre antéro-latéral de cuisse; Localized irradiation; Monoclonal antibodies.
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