Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives

Nanne K H de Boer; Laurent Peyrin-Biroulet; Bindia Jharap; Jeremy D Sanderson; Berrie Meijer; Imke Atreya; Murray L Barclay; Jean-Frederic Colombel; Anthony Lopez; Laurent Beaugerie; Anthony M Marinaki; Adriaan A van Bodegraven; Markus F Neurath

doi:10.1093/ecco-jcc/jjx181

Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives

J Crohns Colitis. 2018 Apr 27;12(5):610-620. doi: 10.1093/ecco-jcc/jjx181.

Affiliations

¹ Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, The Netherlands.
² Department of Gastroenterology and Hepatology and Inserm U954, Nancy University Hospital, Lorraine University, Vandoeuvre-lès-Nancy, France.
³ Department of Gastroenterology, Meander Medical Centre, Amersfoort, The Netherlands.
⁴ Department of Gastroenterology, Guy's and St Thomas' Hospitals, London, UK.
⁵ Department of Gastroenterology, Pneumology and Endocrinology, Universitätsklinikum Erlangen, University of Erlangen-Nürnberg, Germany.
⁶ Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand.
⁷ Department of Gastroenterology, Mount Sinai Hospital, New York, NY, USA.
⁸ Department of Gastroenterology, AP-HP, Hôpital Saint-Antoine,UPMC University, Paris, France.
⁹ Purine Research Laboratory, Guy's and St Thomas' Hospitals, London, UK.
¹⁰ Department of Gastroenterology, Geriatrics, Internal and Intensive Care Medicine [Co-MIK], Zuyderland Medical Centre, Heerlen-Sittard-Geleen, The Netherlands.

PMID: 29293971
DOI: 10.1093/ecco-jcc/jjx181

Abstract

Thiopurines, available as azathioprine, mercaptopurine, and thioguanine, are immunomodulating agents primarily used to maintain corticosteroid-free remission in patients with inflammatory bowel disease. To provide a state-of-the-art overview of thiopurine treatment in inflammatory bowel disease, this clinical review critically summarises the available literature, as assessed by several experts in the field of thiopurine treatment and research in inflammatory bowel disease.

Publication types

Review

MeSH terms

Azathioprine / pharmacology
Azathioprine / therapeutic use*
Drug Therapy, Combination
Gastrointestinal Agents / therapeutic use
Humans
Immunosuppressive Agents / pharmacology
Immunosuppressive Agents / therapeutic use*
Inflammatory Bowel Diseases / drug therapy*
Infliximab / therapeutic use
Mercaptopurine / pharmacology
Mercaptopurine / therapeutic use*
Neoplasms / epidemiology*
Risk Factors
Thioguanine / pharmacology
Thioguanine / therapeutic use*

Substances

Gastrointestinal Agents
Immunosuppressive Agents
Infliximab
Mercaptopurine
Thioguanine
Azathioprine