Modulation of quantum dots and clearance of Helicobacter pylori with synergy of cell autophagy

Yu Huang; Xin Deng; Jian Lang; Xingqiu Liang

doi:10.1016/j.nano.2017.12.016

Modulation of quantum dots and clearance of Helicobacter pylori with synergy of cell autophagy

Nanomedicine. 2018 Apr;14(3):849-861. doi: 10.1016/j.nano.2017.12.016. Epub 2018 Jan 6.

Authors

Yu Huang¹, Xin Deng², Jian Lang¹, Xingqiu Liang³

Affiliations

¹ Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, PR China.
² Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, PR China. Electronic address: [email protected].
³ Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, PR China.

PMID: 29309908
DOI: 10.1016/j.nano.2017.12.016

Abstract

Helicobacter pylori (Hp) is one type of Gram-negative pathogenic bacterium that colonizes and causes a wide range of gastric diseases. Once Hp penetrates into cells, the currently recognized triple or quadruple therapy often loses effectiveness. Recent evidence suggests that autophagy is closely associated with Hp infection, and can play an important role in the eradication of Hp. More importantly, certain types of quantum dots (QDs) can induce and modulate cellular autophagy, and can be developed into conjugates making QDs potential candidates as new anti-Hp agents.

Keywords: Autophagy; Helicobacter pylori (Hp); Quantum dots (QDs).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Anti-Bacterial Agents / therapeutic use*
Autophagy*
Helicobacter Infections / microbiology
Helicobacter Infections / prevention & control*
Helicobacter pylori / drug effects*
Humans
Quantum Dots*

Substances

Anti-Bacterial Agents