IL-6 pathway upregulation in subgroup of severe asthma is associated with neutrophilia and poor lung function

Clin Exp Allergy. 2018 Apr;48(4):475-478. doi: 10.1111/cea.13085. Epub 2018 Feb 19.

Authors

N Turan¹, M J Edwards¹, S Bates¹, D Shaw², K F Chung³, M J Loza⁴, A James⁵, A Van Oosterhout¹; U-BIOPRED Study Group

Affiliations

¹ GlaxoSmithKline, Respiratory R&D, Stevenage, UK.
² Respiratory Research Unit, University of Nottingham, Nottingham, UK.
³ National Heart & Lung Institute, Imperial College, London, UK.
⁴ Janssen Research & Development, Spring House, PA, USA.
⁵ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

PMID: 29315928
DOI: 10.1111/cea.13085

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Asthma / immunology*
Asthma / metabolism*
Female
Humans
Interleukin-6 / analysis
Interleukin-6 / metabolism*
Male
Middle Aged
Neutrophils / immunology*
Respiratory Function Tests
Sputum / immunology
Sputum / metabolism
Up-Regulation

Substances

IL6 protein, human
Interleukin-6