Abstract
Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.
MeSH terms
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Amino Acid Sequence
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Enzyme Activation / drug effects
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Gadolinium / chemistry
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Gallium Radioisotopes
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Heterocyclic Compounds, 1-Ring / chemistry
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Magnetic Resonance Imaging / methods*
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Matrix Metalloproteinase 2 / metabolism*
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Neoplasms / diagnostic imaging*
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Neoplasms / metabolism
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Peptides / chemistry
Substances
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Gallium Radioisotopes
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Heterocyclic Compounds, 1-Ring
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Organometallic Compounds
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Peptides
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1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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Gallium-68
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Gadolinium
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Matrix Metalloproteinase 2