Transplanted human thymus slices induce and support T-cell development in mice after cryopreservation

Eur J Immunol. 2018 Apr;48(4):716-719. doi: 10.1002/eji.201747193. Epub 2018 Feb 1.

Authors

Affiliations

¹ UCL Great Ormond Street Institute of Child Health, London, UK.
² Great Ormond Street Hospital, London, UK.
³ Asymptote Ltd, Sovereign House, Vision Park, Cambridge, UK.
⁴ UCL Division of Surgery and Interventional Science, Royal Free Hospital Campus, London, UK.

Abstract

Nude mouse human thymus transplant model: Fresh or cryopreserved and thawed human thymus slices were transplanted subcutaneously into recipient nude mice. Nude mice subsequently produced mouse CD3⁺ CD4⁺ T-cells.

Keywords: Clinical immunology; Cryopreservation; Thymopoiesis; Thymus transplantation; Transplantation.

© 2018 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD4-Positive T-Lymphocytes / cytology*
CD4-Positive T-Lymphocytes / immunology
Cell Proliferation
Cryopreservation
Humans
Lymphocyte Count
Mice
Mice, Nude
Thymus Gland / cytology*
Thymus Gland / transplantation*
Transplantation, Heterologous

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