Early temperamental fearfulness and the developmental trajectory of error-related brain activity

Dev Psychobiol. 2018 Mar;60(2):224-231. doi: 10.1002/dev.21605. Epub 2018 Jan 18.

Abstract

The error-related negativity (ERN) is a negative deflection in the event-related potential waveform that occurs when an individual makes a mistake, and an increased ERN has been proposed as a biomarker for anxiety. However, previous work suggests that fearful children are characterized by a smaller ERN. We have proposed that this may reflect the changing phenomenology of anxiety across development. In the current study, we investigate this possibility using a longitudinal within-subject design. In 271 children, we completed observational measures of fear when the children were 3 years old, and then measured the ERN when the children were 6 and 9 years old. Fearful children were characterized by a decreased ERN when they were 6-year-old; by age 9, the same children who were fearful at age 3 had increased ERNs-a pattern that closely resembles that of anxious adolescents and adults.

Keywords: anxiety; electrophysiology; error-related negativity; response monitoring; temperament.

MeSH terms

  • Anxiety / physiopathology*
  • Child
  • Child Development / physiology*
  • Child, Preschool
  • Electroencephalography
  • Evoked Potentials / physiology*
  • Fear / physiology*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Temperament / physiology*