Abstract
The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) to control tissue growth in many different cell types. Previously, we demonstrated that Yap is a critical regulator of skeletal muscle mass. We hypothesize that alterations in Yap and Taz activity modulate the anabolic adaptations of skeletal muscle to resistance exercise.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptation, Physiological
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Cell Cycle Proteins
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DNA-Binding Proteins / metabolism
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Gene Expression
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Hippo Signaling Pathway
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Humans
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Intracellular Signaling Peptides and Proteins / genetics
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Muscle Fibers, Skeletal / metabolism
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Muscle, Skeletal / anatomy & histology*
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Muscle, Skeletal / growth & development
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Muscle, Skeletal / metabolism*
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Protein Serine-Threonine Kinases / metabolism*
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Resistance Training*
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Signal Transduction*
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TEA Domain Transcription Factors
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Trans-Activators
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcriptional Coactivator with PDZ-Binding Motif Proteins
Substances
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Cell Cycle Proteins
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DNA-Binding Proteins
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Intracellular Signaling Peptides and Proteins
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Nuclear Proteins
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TEA Domain Transcription Factors
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TEAD1 protein, human
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Trans-Activators
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Transcription Factors
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Transcriptional Coactivator with PDZ-Binding Motif Proteins
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WWTR1 protein, human
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YY1AP1 protein, human
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Protein Serine-Threonine Kinases