Background: We describe three children with Angelman syndrome and medically refractory epilepsy.
Methods: Case series of three pediatric patients with Angelman syndrome and medically refractory epilepsy. All three patients failed medical treatment and were recommended for vagal nerve stimulator (VNS) implantation.
Results: Following VNS implantation, all three patients experienced reduction in seizure frequency greater than that afforded by medication alone.
Conclusion: We present vagal nerve stimulator implantation as a viable treatment option for medically refractory epilepsy associated with Angelman syndrome.
Keywords: Angelman syndrome; Medically refractory epilepsy; Vagal nerve stimulation.