Dipeptidyl peptidase IV, which probably plays important roles in Alzheimer disease (AD) pathology, is upregulated in AD brain neurons and associates with amyloid plaques

Neurochem Int. 2018 Mar:114:55-57. doi: 10.1016/j.neuint.2018.01.005. Epub 2018 Jan 17.

Abstract

There is evidence from in vitro experiments that dipeptidyl peptidase IV (DPP IV) might play role(s) in amyloid formation. However, nothing is known about the localization of the enzyme in brains of individuals with Alzheimer's disease. We herein show that in comparison to non-demented controls DPP IV is upregulated in AD brain neurons and occurs in multiple amyloid plaques.

Keywords: Alzheimer's disease; Amyloid; DPP IV; Immunohistochemistry; Neurons.

Publication types

  • Letter

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / enzymology*
  • Animals
  • Brain / drug effects
  • Brain / enzymology*
  • Dipeptidyl Peptidase 4 / biosynthesis*
  • Dipeptidyl-Peptidase IV Inhibitors / pharmacology
  • Dipeptidyl-Peptidase IV Inhibitors / therapeutic use
  • Humans
  • Neurons / drug effects
  • Neurons / enzymology*
  • Plaque, Amyloid / drug therapy
  • Plaque, Amyloid / enzymology*
  • Up-Regulation / drug effects
  • Up-Regulation / physiology*

Substances

  • Dipeptidyl-Peptidase IV Inhibitors
  • DPP4 protein, human
  • Dipeptidyl Peptidase 4