Automated radiosynthesis of Al[18F]PSMA-11 for large scale routine use

Ken Kersemans; Kathia De Man; Jan Courtyn; Tessa Van Royen; Sarah Piron; Lieselotte Moerman; Boudewijn Brans; Filip De Vos

doi:10.1016/j.apradiso.2018.01.006

Automated radiosynthesis of Al[¹⁸F]PSMA-11 for large scale routine use

Appl Radiat Isot. 2018 May:135:19-27. doi: 10.1016/j.apradiso.2018.01.006. Epub 2018 Jan 12.

Authors

Ken Kersemans¹, Kathia De Man², Jan Courtyn², Tessa Van Royen³, Sarah Piron³, Lieselotte Moerman², Boudewijn Brans², Filip De Vos³

Affiliations

¹ Ghent University Hospital, Nuclear Medicine, De Pintelaan 185, Ghent, Belgium. Electronic address: [email protected].
² Ghent University Hospital, Nuclear Medicine, De Pintelaan 185, Ghent, Belgium.
³ Laboratory of Radiopharmacy, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium.

PMID: 29353193
DOI: 10.1016/j.apradiso.2018.01.006

Abstract

Objectives: We report a reproducible automated radiosynthesis for large scale batch production of clinical grade Al[¹⁸F]PSMA-11.

Methods: A SynthraFCHOL module was optimized to synthesize Al[¹⁸F]PSMA-11 by Al[¹⁸F]-chelation. Results Al[¹⁸F]PSMA-11 was synthesized within 35min in a yield of 21 ± 3% (24.0 ± 6.0GBq) and a radiochemical purity > 95%. Batches were stable for 4h and conform the European Pharmacopeia guidelines.

Conclusions: The automated synthesis of Al[¹⁸F]PSMA-11 allows for large scale production and distribution of Al[¹⁸F]PSMA-11.

Keywords: AlF(2+); Automation; Chelation; PSMA; Prostate cancer.