Photoacoustic-Enabled Self-Guidance in Magnetic-Hyperthermia Fe@Fe3 O4 Nanoparticles for Theranostics In Vivo

Adv Healthc Mater. 2018 May;7(9):e1701201. doi: 10.1002/adhm.201701201. Epub 2018 Jan 22.

Abstract

Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe3 O4 nanoparticles (RGD-PEG-MNPs) are developed for photoacoustic (PA)-enabled self-guidance in tumor-targeting magnetic hyperthermia therapy in vivo. In the αv β3 -positive U87MG glioblastoma xenograft model, the PA signal of RGD-PEG-MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2-folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD-PEG-MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD-PEG-MNPs.

Keywords: Fe@Fe3O4 nanoparticles; PA imaging; in vivo theranostics; magnetic hyperthermia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Glioblastoma / metabolism
  • Glioblastoma / pathology
  • Glioblastoma / therapy*
  • Humans
  • Hyperthermia, Induced / methods*
  • Magnetic Field Therapy / methods*
  • Magnetite Nanoparticles* / chemistry
  • Magnetite Nanoparticles* / therapeutic use
  • Mice, Inbred BALB C
  • Mice, Nude
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology
  • Photoacoustic Techniques / methods*
  • Theranostic Nanomedicine / methods*
  • Xenograft Model Antitumor Assays

Substances

  • Magnetite Nanoparticles
  • Oligopeptides
  • arginyl-glycyl-aspartic acid