Abstract
Infantile myofibromatosis is a mesenchymal disorder characterized by the fibrous proliferation of the skin, bone, muscle and viscera. It is the most common fibrous tumor in childhood. We present a newborn with skin and bone disease without visceral involvement, who showed good response to vinblastine and methotrexate. Clinical features, etiology, diagnosis, and treatment are reviewed.
MeSH terms
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Dermatologic Agents / therapeutic use
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Humans
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Immunohistochemistry
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Infant, Newborn
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Male
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Methotrexate / therapeutic use
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Myofibromatosis / congenital*
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Myofibromatosis / drug therapy
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Myofibromatosis / pathology
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Treatment Outcome
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Vinblastine / therapeutic use
Substances
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Dermatologic Agents
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Vinblastine
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Methotrexate
Supplementary concepts
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Fibromatosis, Congenital Generalized