Long-term physical activity leads to a significant increase in serum sRAGE levels: a sign of decreased AGE-mediated inflammation due to physical activity?

Heart Vessels. 2018 Aug;33(8):893-900. doi: 10.1007/s00380-018-1125-5. Epub 2018 Jan 24.

Abstract

There is growing evidence that low levels of the circulating soluble receptor of advanced glycation end products (sRAGE) are a valuable predictor of cardiovascular disease (CVD). The aim of this prospective study was to investigate the influence of long-term physical activity on serum sRAGE levels. 109 subjects were recruited, and 98 completed the study. Participants were asked to perform exercise within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. sRAGE was measured at baseline and after 2/6/8 months by ELISA. Backwards, multiple linear regression analysis was performed to investigate the association of co-variables age, sex, BMI, and performance at baseline, HbA1c, and lipoprotein a with baseline sRAGE levels. We identified BMI and lipoprotein a as significant predictors for baseline sRAGE levels. Compared to subjects with a performance gain ≤ 4.9% subjects with a gain > 5% showed a significant increase in sRAGE levels up to 22%. sRAGE serum levels correlate negatively with lipoprotein a levels and BMI and long-term physical activity leads to a significant increase in serum sRAGE levels (9-22%), whereby the sRAGE increase is most pronounced in subjects with initially low-performance levels, suggesting that in particular, these subject profit the most from increased physical activity. The sport-mediated increase of sRAGE might be a sign of decreased AGE-mediated inflammation and highlight the protective effect of sports on CVD and other disease which are at least partly mediated by an increased inflammation status.Clinical trials registration NCT02097199.

Keywords: Advanced glycation end products; Inflammation; Physical activity; RAGE; sRAGE.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / physiopathology
  • Enzyme-Linked Immunosorbent Assay
  • Exercise / physiology*
  • Exercise Test
  • Female
  • Follow-Up Studies
  • Glycation End Products, Advanced / blood*
  • Humans
  • Inflammation / blood*
  • Inflammation Mediators / blood*
  • Male
  • Middle Aged
  • Prospective Studies
  • Receptor for Advanced Glycation End Products / blood*
  • Time Factors

Substances

  • Biomarkers
  • Glycation End Products, Advanced
  • Inflammation Mediators
  • Receptor for Advanced Glycation End Products
  • sRAGE protein, human

Associated data

  • ClinicalTrials.gov/NCT02097199