Metastatic HPV-related oropharyngeal carcinoma cured with chemoradiotherapy: importance of pretherapy biomolecular assessment

Francesco Perri; Francesco Longo; Giuseppina Della Vittoria Scarpati; Salvatore Pisconti; Vito Longo; Raffaele Addeo; Fabio Carducci; Carlo Buonerba; Franco Fulciniti; Raffaele Solla

doi:10.1002/ccr3.1107

Metastatic HPV-related oropharyngeal carcinoma cured with chemoradiotherapy: importance of pretherapy biomolecular assessment

Clin Case Rep. 2017 Nov 24;6(1):56-62. doi: 10.1002/ccr3.1107. eCollection 2018 Jan.

Authors

Affiliations

¹ Medical Oncology Department POC SS Annunziata Taranto Italy.
² Otolaryngology Unit National Tumour Institute of Naples, G Pascale Naples Italy.
³ Department of Medical Oncology Hospital S Giovanni di Dio Naples Italy.
⁴ Otolaryngology Unit POC SS Annunziata Taranto Italy.
⁵ Medical Oncology Department University Federico II of Naples Naples Italy.
⁶ Pathology Unit Clinica Luganese Lugano Switzerland.
⁷ Institute of Biostructure and Bioimaging National Council of Research Naples Italy.
⁸ Department of Advanced Biomedical Sciences Federico II University School of Medicine Naples Italy.

Abstract

Pretherapy assessment has a crucial role in the management of advanced oropharyngeal carcinoma. The case report represents an example of how translational research may help to optimize the therapeutic options and to choose a well-shaped therapy adapted to the tumor and the patient.

Keywords: Cyclin D1; P16; human papillomavirus; oropharyngeal carcinoma; p53.

Publication types

Case Reports