Leukemic phase and CSF involvement of diffuse large B-cell lymphoma with a complex karyotype including a TP53 deletion

Jillian Sinkoff; Horatiu Olteanu; Jess F Peterson; Nirav N Shah

doi:10.1002/ccr3.1250

Leukemic phase and CSF involvement of diffuse large B-cell lymphoma with a complex karyotype including a TP53 deletion

Clin Case Rep. 2017 Dec 5;6(1):235-237. doi: 10.1002/ccr3.1250. eCollection 2018 Jan.

Authors

Jillian Sinkoff¹, Horatiu Olteanu², Jess F Peterson², Nirav N Shah¹

Affiliations

¹ Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin.
² Department of Pathology Froedtert/MCW Laboratory Building Milwaukee Wisconsin.

Abstract

Diffuse large B-cell lymphoma in rare instances can present initially in a leukemic phase and mimic other lymphoid diseases. In such cases, advanced diagnostic testing including immunophenotyping, FISH analysis, and karyotyping can help determine the accurate diagnosis which is key in the management of the disease.

Keywords: DLBCL; NHL; TP53 deletion.