Abstract
Delayed hypersensitivity reaction in mice was enhanced with various anti-cancer drugs administered at the site of antigenic stimulation during 4 days following sensitization. The immunopotentiating effect of the presented local chemotherapy protocol is thought to result from impairment of a regulatory circuit, with activated suppressor T cells (Ts) as target rather than Ts precursors or Ts-inducing antigen-presenting cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Cell Cycle / drug effects
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Cisplatin / pharmacology
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Cyclophosphamide / analogs & derivatives
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Cyclophosphamide / pharmacology
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Dose-Response Relationship, Drug
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Doxorubicin / pharmacology
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Erythrocytes / immunology
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Etoposide / pharmacology
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Hypersensitivity, Delayed / immunology*
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Immunity, Cellular / drug effects*
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Male
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Mice
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Mice, Inbred DBA
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Sheep
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T-Lymphocytes, Regulatory / drug effects
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Time Factors
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Vincristine / pharmacology
Substances
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Antineoplastic Agents
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Vincristine
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Etoposide
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Doxorubicin
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Asta Z 7557
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Cyclophosphamide
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Cisplatin