Crosstalk between prognostic long noncoding RNAs and messenger RNAs as transcriptional hallmarks in gastric cancer

Epigenomics. 2018 Apr 1;10(4):433-443. doi: 10.2217/epi-2017-0136. Epub 2018 Feb 6.

Abstract

Aim: Our study investigated the significance of the crosstalk between long noncoding RNAs (lncRNAs) and mRNAs in gastric cancer (GC).

Methods: lncRNA and mRNA expression profiling data in 671 GC tumors and 77 nontumorous gastric tissues were retrieved from the gene expression omnibus database: GSE54129, GSE13911, GSE19826, GSE79973, GSE15459 and GSE66229. Differentially expressed analysis, RNA coexpression network construction, gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses were conducted in this study.

Results: Using differentially expressed and prognostic lncRNAs or mRNAs in GC, we constructed the lncRNA-mRNA coexpression networks. This network involved with vital GO and KEGG pathways.

Conclusion: Our study reveals coexpressed lncRNAs and mRNAs as transcriptional hallmarks in GC patients which provide interesting information regarding the incidence and outcome of GC.

Keywords: long noncoding RNA; messenger RNA; stomach neoplasms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Profiling
  • Kaplan-Meier Estimate
  • Prognosis
  • RNA, Long Noncoding / metabolism*
  • RNA, Messenger / metabolism*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / mortality
  • Transcription, Genetic

Substances

  • RNA, Long Noncoding
  • RNA, Messenger