Melanoma mimicking Rosai-Dorfman disease

J Cutan Pathol. 2018 May;45(5):355-359. doi: 10.1111/cup.13121. Epub 2018 Mar 1.

Abstract

Despite well-defined clinical and histopathological features of melanoma, atypical presentations mimicking other skin disorders can result in a delayed diagnosis or misdiagnosis and subsequent inappropriate treatment. Rosai-Dorfman disease (RDD) is a rare histiocytic disorder with unique clinical and histopathological features. We report a case of melanoma treated with cryotherapy that mimicked RDD both clinically and histopathologically. We compare this RDD-like melanoma to classic RDD, outlining the importance of clinicopathological correlation prior to treatment, as well as the potential pitfalls in diagnosis after cryotherapy of pigmented lesions.

Keywords: Rosai-Dorfman disease; cryotherapy; melanoma; mimicker.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Female
  • Histiocytosis, Sinus / diagnosis*
  • Histiocytosis, Sinus / pathology
  • Humans
  • Melanoma / diagnosis*
  • Melanoma / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology