(3+2) Cycloadditions of Thiouronium Ylides: A Room-Temperature, One-Pot Approach to Dihydrothiophenes

J Org Chem. 2018 Feb 16;83(4):2479-2485. doi: 10.1021/acs.joc.7b03255. Epub 2018 Feb 6.

Abstract

A room-temperature (3+2) cycloaddition sequence for the synthesis of highly substituted dihydrothiophene derivatives has been developed. By utilizing structurally unique thiocarbonyl ylides, the reactivity of these traditionally high-energy intermediates can be modulated, enabling a synthetically useful transformation to proceed under mild conditions.

Publication types

  • Research Support, Non-U.S. Gov't