Heterozygous carriers of germline c.657_661del5 founder mutation in NBN gene are at risk of central nervous system relapse of B-cell precursor acute lymphoblastic leukemia

Haematologica. 2018 May;103(5):e200-e203. doi: 10.3324/haematol.2017.181198. Epub 2018 Feb 1.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Cell Cycle Proteins / genetics*
  • Central Nervous System Neoplasms / etiology*
  • Central Nervous System Neoplasms / pathology
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Founder Effect
  • Germ-Line Mutation*
  • Heterozygote*
  • Humans
  • Infant
  • Male
  • Neoplasm Recurrence, Local / etiology*
  • Neoplasm Recurrence, Local / pathology
  • Nuclear Proteins / genetics*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Survival Rate

Substances

  • Cell Cycle Proteins
  • NBN protein, human
  • Nuclear Proteins