Three new alkaloids from Xylopia vielana and their antiinflammatory activities

Fitoterapia. 2018 Jun:127:96-100. doi: 10.1016/j.fitote.2018.02.001. Epub 2018 Feb 5.

Abstract

Three new aporphine alkaloids, xylopialoids A-C (1-3), along with three known aporphine alkioids (4-6) and three other known compounds (7-9) were isolated from the roots of Xylopia vielana. Among these three new aporphine alkaloids, xylopialoid C (3) showed a special carbamido group directly connected to the nitrogen. The chemical structures of these nine compounds were determined by a combination of 1D and 2D NMR, MS, CD spectrum and Cu Kα X-ray crystallographic analyses. All these six alkaloids were firstly tested for the inhibitory activities against the production of NO in RAW264.7 cells stimulated by lipopolysaccharide (LPS). Among these compounds, 4 showed a potential inhibitory activity against the production of nitric oxide with IC50 value of 1.39 μM.

Keywords: Alkaloids; Antiinflammatory activities; Xylopia vielana.

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Roots / chemistry*
  • RAW 264.7 Cells
  • Xylopia / chemistry*

Substances

  • Alkaloids
  • Anti-Inflammatory Agents
  • Nitric Oxide