Multicenter, multivendor phantom study to validate proton density fat fraction and T2* values calculated using vendor-provided 6-point DIXON methods

Tatsuya Hayashi; Kei Fukuzawa; Hidekazu Yamazaki; Takashi Konno; Tosiaki Miyati; Jun'ichi Kotoku; Hiroshi Oba; Hiroshi Kondo; Keiko Toyoda; Satoshi Saitoh

doi:10.1016/j.clinimag.2018.01.011

Multicenter, multivendor phantom study to validate proton density fat fraction and T2* values calculated using vendor-provided 6-point DIXON methods

Clin Imaging. 2018 Sep-Oct:51:38-42. doi: 10.1016/j.clinimag.2018.01.011. Epub 2018 Feb 2.

Authors

Affiliations

¹ Graduate School of Medical Technology, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. Electronic address: [email protected].
² Department of Radiological Technology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan; Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan.
³ Department of Radiological Technology, Southern TOHOKU General Hospital, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, Japan.
⁴ Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan.
⁵ Graduate School of Medical Technology, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
⁶ Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
⁷ Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan; Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan.

PMID: 29425901
DOI: 10.1016/j.clinimag.2018.01.011

Abstract

Purpose: To evaluate the reproducibility of proton density fat fraction (PDFF) and T2* in a fat-water phantom on three different 3 T MRI systems using 6-point DIXON methods.

Methods: A phantom which included varying fat volume percentages (true fat fraction [FF]) was scanned by three 3 T MR machines, and PDFF and T2* were measured.

Results: The mean difference between true FF and PDFF was small in all vendors (-2.11% to 0.41%). However, the difference ratio for T2* values was large among vendors (1.79 to 3.36).

Conclusions: True FF and PDFF were consistent across vendors; however, T2* varied greatly.

Keywords: DIXON; Fat; Liver; MRI; Phantom; Quantification.

Publication types

Multicenter Study
Validation Study

MeSH terms

Adipose Tissue / metabolism*
Adipose Tissue / physiology
Algorithms*
Commerce
Humans
Iron / metabolism
Liver / diagnostic imaging
Liver / metabolism
Liver / pathology*
Magnetic Resonance Imaging / instrumentation
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods
Non-alcoholic Fatty Liver Disease / metabolism
Non-alcoholic Fatty Liver Disease / pathology*
Phantoms, Imaging*
Protons*
Reproducibility of Results
Software
Water / metabolism

Substances

Protons
Water
Iron