Safety of rAAV2/2-ND4 Gene Therapy for Leber Hereditary Optic Neuropathy

Ophthalmology. 2018 Jun;125(6):945-947. doi: 10.1016/j.ophtha.2017.12.036. Epub 2018 Feb 14.
No abstract available

Publication types

  • Clinical Trial, Phase I
  • Clinical Trial, Phase II
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Color Vision / physiology
  • Contrast Sensitivity / physiology
  • Dependovirus / genetics*
  • Electroretinography
  • Evoked Potentials, Visual / physiology
  • Female
  • Genetic Therapy / adverse effects*
  • Genetic Therapy / methods*
  • Genetic Vectors*
  • Humans
  • Intravitreal Injections
  • Male
  • Middle Aged
  • NADH Dehydrogenase / genetics*
  • Optic Atrophy, Hereditary, Leber / genetics
  • Optic Atrophy, Hereditary, Leber / physiopathology
  • Optic Atrophy, Hereditary, Leber / therapy*
  • Prospective Studies
  • Visual Acuity / physiology

Substances

  • NADH dehydrogenase subunit 4
  • NADH Dehydrogenase