Abstract
A novel class of C38N4 Lycopodium alkaloid, hupercumine A (1), consisting of two octahydroquinolines, a decahydroquinoline, and a piperidine, and a new C27N3-type alkaloid, hupercumine B (2), were isolated from Huperzia cunninghamioides (Hayata) Holub. The structures and absolute configurations of 1 and 2 were elucidated on the basis of spectroscopic data, chemical means, and biogenetic point of view. Hupercumines A (1) and B (2) showed moderate inhibitory activity against acetylcholinesterase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / chemistry
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Cholinesterase Inhibitors / chemistry*
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Cholinesterase Inhibitors / isolation & purification
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Huperzia / chemistry*
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Lycopodium / chemistry*
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Molecular Structure
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Piperidines / chemistry*
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Piperidines / isolation & purification
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Quinolines / chemistry*
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Quinolines / isolation & purification
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Stereoisomerism
Substances
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Alkaloids
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Cholinesterase Inhibitors
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Piperidines
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Plant Extracts
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Quinolines
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decahydroquinoline-5-carboxylic acid
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Acetylcholinesterase