Exogenous human herpesvirus 6 reinfection after tumor-infiltrating T-lymphocyte therapy

Cytotherapy. 2018 Apr;20(4):521-523. doi: 10.1016/j.jcyt.2017.12.006. Epub 2018 Feb 9.

Abstract

Exogenous human herpes virus 6 (HHV-6) reinfection has never been reported in patients receiving tumor-infiltrating T lymphocytes therapy. We report an unusual case of HHV-6 infection following infusion of HHV-6 infected autologous T lymphocytes. HHV-6 infection could interfere with the tumor antigen immune recognition and the efficacy of immunotherapy.

Keywords: Human herpesvirus 6 (HHV-6); immunotherapy; reinfection; tumor-infiltrating T lymphocyte therapy (TIL).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Axilla
  • Drug Contamination
  • Female
  • Herpesvirus 6, Human / physiology*
  • Humans
  • Iatrogenic Disease
  • Immunotherapy, Adoptive / adverse effects*
  • Lymphatic Metastasis
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Lymphocytes, Tumor-Infiltrating / transplantation*
  • Lymphocytes, Tumor-Infiltrating / virology*
  • Melanoma / complications
  • Melanoma / pathology
  • Melanoma / therapy*
  • Melanoma / virology
  • Recurrence
  • Roseolovirus Infections / diagnosis
  • Roseolovirus Infections / etiology*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy*
  • Skin Neoplasms / virology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / transplantation
  • T-Lymphocytes / virology