Abstract
It is unclear whether priming of naïve T cells to drugs is detectable in healthy human donors expressing different human leukocyte antigen (HLA) alleles. Thus, we examined T cell priming with drugs associated with HLA risk alleles and control compounds in 14 HLA-typed donors. Nitroso sulfamethoxazole and piperacillin activated T cells from all donors, whereas responses to carbamazepine and oxypurinol were only seen in donors expressing HLA-B*15:02 and HLA-B*58:01, respectively. Weak flucloxacillin-specific T cell responses were detected in donors expressing HLA-B*57:01 and HLA-B*58:01. These data show that the priming of T cells with certain drugs is skewed toward donors expressing specific HLA alleles.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / adverse effects
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Anti-Infective Agents / immunology
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Anticonvulsants / adverse effects
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Anticonvulsants / immunology
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Carbamazepine / adverse effects
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Carbamazepine / immunology
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Drug-Related Side Effects and Adverse Reactions / immunology*
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Enzyme Inhibitors / adverse effects
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Enzyme Inhibitors / immunology
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HLA Antigens / immunology*
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HLA-B Antigens / immunology
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Humans
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Lymphocyte Activation / drug effects*
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Nitroso Compounds / adverse effects
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Nitroso Compounds / immunology
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Oxypurinol / adverse effects
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Oxypurinol / immunology
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Piperacillin / adverse effects
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Piperacillin / immunology
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Sulfamethoxazole / adverse effects
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Sulfamethoxazole / immunology
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T-Lymphocytes / drug effects*
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T-Lymphocytes / immunology
Substances
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Anti-Infective Agents
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Anticonvulsants
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Enzyme Inhibitors
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HLA Antigens
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HLA-B Antigens
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Nitroso Compounds
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Carbamazepine
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Oxypurinol
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Sulfamethoxazole
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Piperacillin