Abstract
Cdc48/p97 and the ubiquilin family of UBA-UBL proteins are known for their role in the retrotranslocation of damaged proteins from the endoplasmic reticulum. We demonstrate that Cdc48 and the ubiquilin-like proteins in yeast also play a role in the anterograde trafficking of proteins, in this case the vacuolar protease, Cps1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Autophagy
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Carboxypeptidases / genetics
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Carboxypeptidases / metabolism
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Cell Cycle Proteins / metabolism
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Endoplasmic Reticulum / metabolism
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Multivesicular Bodies / metabolism
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Nuclear Proteins / metabolism
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Nucleocytoplasmic Transport Proteins / genetics
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Nucleocytoplasmic Transport Proteins / metabolism
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Proteasome Endopeptidase Complex / metabolism
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Protein Transport
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / enzymology*
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Saccharomyces cerevisiae / ultrastructure
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism*
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Ubiquitin / metabolism*
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Valosin Containing Protein / genetics
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Valosin Containing Protein / metabolism*
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Vesicular Transport Proteins / genetics
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Vesicular Transport Proteins / metabolism
Substances
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Cell Cycle Proteins
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DDI1 protein, S cerevisiae
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NPL4 protein, S cerevisiae
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Nuclear Proteins
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Nucleocytoplasmic Transport Proteins
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Saccharomyces cerevisiae Proteins
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UFD1 protein, S cerevisiae
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Ubiquitin
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Vesicular Transport Proteins
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Carboxypeptidases
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CPS1 protein, S cerevisiae
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Proteasome Endopeptidase Complex
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CDC48 protein, S cerevisiae
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Valosin Containing Protein