25-OH-vitamin D, parathyroid hormone, and calcium serum levels in captive common marmosets (Callithrix jacchus): Reference values and effect of age, sex, season, and closure of long bone epiphyses

J Med Primatol. 2018 Jun;47(3):172-177. doi: 10.1111/jmp.12334. Epub 2018 Feb 15.

Abstract

Background: To date, reference values for 25-OH-vitamin D, parathyroid hormone (PTH), and calcium in serum of common marmosets (Callithrix jacchus) based on a large sample size are not available.

Methods: Serum reference values for these parameters were determined and correlated with sex, age, season of sampling, and time of long bone epiphyseal closure in captive-housed marmosets.

Results and conclusions: The 90% reference range for serum 25-OH-vitamin D is 47.40-370.4 nmol/L, for PTH 2.10-30.51 pmol/L, and for calcium 2.08-2.63 mmol/L. Lower levels of vitamin D were measured in fall compared with the other seasons. Levels of PTH were higher in males than in females, and calcium levels were lower in younger animals compared with older marmosets. No other effects of age, sex, season, or timing of growth plate closure were found.

Keywords: blood biochemistry; bone growth; growth plate; new world monkey.

MeSH terms

  • Age Factors
  • Animals
  • Calcium / blood*
  • Callithrix / metabolism*
  • Epiphyses / growth & development
  • Female
  • Growth Plate / growth & development*
  • Male
  • Parathyroid Hormone / blood*
  • Reference Values
  • Seasons
  • Sex Factors
  • Vitamin D / blood*

Substances

  • Parathyroid Hormone
  • Vitamin D
  • Calcium