Abstract
We investigated influenza A(H5N6) viruses from migratory birds in Chungnam and Gyeonggi Provinces, South Korea following a reported die-off of poultry in nearby provinces in November 2017. Genetic analysis and virulence studies in chickens and ducks identified our isolate from December 2017 as a novel highly pathogenic avian influenza virus. It resulted from reassortment between the highly virulent H5N8 strain from Korea with the N6 gene from a low-pathogenic H3N6 virus from the Netherlands.
Keywords:
H5N6; Highly pathogenic avian influenza (HPAI); Influenza A virus; Reassortant; South Korea; Virulence.
MeSH terms
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Animal Migration
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Animals
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Chickens / virology*
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Disease Outbreaks / veterinary
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Ducks / virology*
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Humans
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Influenza A Virus, H5N8 Subtype / classification
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Influenza A Virus, H5N8 Subtype / genetics*
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Influenza A Virus, H5N8 Subtype / isolation & purification
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Influenza A Virus, H5N8 Subtype / pathogenicity*
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Influenza A virus / genetics
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Influenza A virus / isolation & purification
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Influenza A virus / pathogenicity*
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Influenza in Birds / epidemiology
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Influenza in Birds / pathology
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Influenza in Birds / virology*
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Netherlands
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Phylogeny
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Poultry Diseases / epidemiology
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Poultry Diseases / pathology
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Poultry Diseases / virology
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Reassortant Viruses* / classification
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Reassortant Viruses* / genetics
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Reassortant Viruses* / isolation & purification
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Reassortant Viruses* / pathogenicity
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Republic of Korea / epidemiology
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Seasons
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Virulence*
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Virus Replication