Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages

Xianfa Yang; Boqiang Hu; Yu Hou; Yunbo Qiao; Ran Wang; Yingying Chen; Yun Qian; Su Feng; Jun Chen; Chang Liu; Guangdun Peng; Fuchou Tang; Naihe Jing

doi:10.1038/s41422-018-0010-1

Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages

Cell Res. 2018 May;28(5):593-596. doi: 10.1038/s41422-018-0010-1. Epub 2018 Feb 20.

Authors

Xianfa Yang^{1

2}, Boqiang Hu³, Yu Hou³, Yunbo Qiao^{4

5}, Ran Wang¹, Yingying Chen¹, Yun Qian¹, Su Feng¹, Jun Chen^{1

6}, Chang Liu¹, Guangdun Peng¹, Fuchou Tang^{7

8

9}, Naihe Jing^{10

11}

Affiliations

¹ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.
² School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
³ Beijing Advanced Innovation Center for Genomics (ICG) and Biomedical Institute for Pioneering Investigation via Convergence, College of Life Sciences, Peking University, Beijing, 100871, China.
⁴ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China. [email protected].
⁵ Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, Guangdong, 510006, China. [email protected].
⁶ Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
⁷ Beijing Advanced Innovation Center for Genomics (ICG) and Biomedical Institute for Pioneering Investigation via Convergence, College of Life Sciences, Peking University, Beijing, 100871, China. [email protected].
⁸ Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, 100871, China. [email protected].
⁹ Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China. [email protected].
¹⁰ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China. [email protected].
¹¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. [email protected].

No abstract available

Publication types

Letter

MeSH terms

Animals
Cell Lineage / genetics*
Cell Plasticity / genetics*
CpG Islands / genetics
DNA / genetics
DNA Methylation / genetics*
Embryo Implantation
Embryo, Mammalian / cytology*
Embryo, Mammalian / metabolism
Epigenesis, Genetic
Gene Silencing*
Genes, Developmental*
Histones / metabolism*
Lysine / metabolism*
Mice
Promoter Regions, Genetic / genetics

Substances

Histones
DNA
Lysine