Recently, most of evidence shows that caloric restriction could induce antidepressant-like effects in animal model of depression. Based on studies of the brain-gut axis, some signal pathways were common between the control of caloric restriction and depression. However, the specific mechanism of the antidepressant-like effects induced by caloric restriction remains unclear. Therefore, in this article, we summarized clinical and experimental studies of caloric restriction on depression. This review may provide a new therapeutic strategy for depression.
Keywords: BDNF; antidepressant; calorie restriction; fasting.
© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.