Abstract
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
MeSH terms
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Actinomycetales / chemistry
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Chromatography, High Pressure Liquid
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Lactams / chemistry
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Lactams, Macrocyclic / chemistry
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Lactams, Macrocyclic / isolation & purification*
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Lactams, Macrocyclic / pharmacology*
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
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Spectrophotometry, Ultraviolet
Substances
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Anti-Bacterial Agents
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Lactams
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Lactams, Macrocyclic