Therapeutic apheresis in the treatment of catastrophic antiphospholipid syndrome

Gökhan Özgür; Cengiz Beyan

doi:10.1016/j.transci.2018.02.008

Therapeutic apheresis in the treatment of catastrophic antiphospholipid syndrome

Transfus Apher Sci. 2018 Feb;57(1):13-15. doi: 10.1016/j.transci.2018.02.008. Epub 2018 Feb 20.

Authors

Gökhan Özgür¹, Cengiz Beyan²

Affiliations

¹ Gulhane Training and Research Hospital, Department of Hematology, Ankara, Turkey. Electronic address: [email protected].
² TOBB University of Economics and Technology, Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey.

PMID: 29478799
DOI: 10.1016/j.transci.2018.02.008

Abstract

Catastrophic thrombotic syndrome is characterized by occurrence of several thromboembolic occlusions which affect a variety of vascular beds over a short period of time. Catastrophic Antiphospholipid syndrome (CAPS) (1%) is regarded as a rare but severe variant of Antiphospholipid Syndrome. Treatment with anticoagulants, steroids and therapeutic plasma exchange has been shown to give the best results. However, to treat CAPS, the best substitute for plasma is still a debatable issue because there are no standard methods.

Keywords: Apheresis; Catastrophic antiphospholipid syndrome; Therapeutic plasma exchange.

Publication types

Review

MeSH terms

Anticoagulants / therapeutic use*
Antiphospholipid Syndrome / complications
Antiphospholipid Syndrome / therapy*
Humans
Plasma Exchange / methods*
Steroids / therapeutic use*
Thromboembolism / etiology
Thromboembolism / therapy*

Substances

Anticoagulants
Steroids