Long-term follow-up of cardiorespiratory outcomes in children born extremely preterm: Recommendations from a Canadian consensus workshop

Sherri Lynne Katz; Thuy Mai Luu; Anne-Monique Nuyt; Thierry Lacaze; Kristi Brae Adamo; Ian Adatia; Tilman Humpl; Robert Peter Jankov; Theo J Moraes; Katharina Staub; Michael K Stickland; Bernard Thebaud; Long-term Cardio-Respiratory Outcomes of Extremely Preterm Infants Working Group

doi:10.1093/pch/pxx028

Long-term follow-up of cardiorespiratory outcomes in children born extremely preterm: Recommendations from a Canadian consensus workshop

Paediatr Child Health. 2017 May;22(2):75-79. doi: 10.1093/pch/pxx028. Epub 2017 Apr 17.

Authors

Sherri Lynne Katz^{1

2}, Thuy Mai Luu^{3

4

5}, Anne-Monique Nuyt^{6

7}, Thierry Lacaze^{8

9

10}, Kristi Brae Adamo¹¹, Ian Adatia^{12

13

14}, Tilman Humpl^{15

16}, Robert Peter Jankov^{17

18

19}, Theo J Moraes^{20

21}, Katharina Staub²², Michael K Stickland^{23

24}, Bernard Thebaud^{25

26

27}; Long-term Cardio-Respiratory Outcomes of Extremely Preterm Infants Working Group

Affiliations

¹ Division of Respiratory Medicine, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario.
² Faculty of Medicine, University of Ottawa, Ottawa, Ontario.
³ Division of General Pediatrics, Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec.
⁴ Faculty of Medicine, Université de Montréal, Montreal, Quebec.
⁵ CHU Sainte-Justine Research Center, Montreal, Quebec.
⁶ Department of Pediatrics, Université de Montréal, Montreal, Quebec.
⁷ Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec.
⁸ Department of Pediatrics, University of Ottawa, Ottawa, Ontario.
⁹ Clinical Research Unit, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario.
¹⁰ Evidence to Practice Research Program, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario.
¹¹ Faculty of Health Sciences, School of Human Kinetics, University of Ottawa, Ottawa, Ontario.
¹² Pediatric Cardiac Intensive Care Unit and Pulmonary Hypertension Service, Stollery Children's Hospital, Edmonton, Alberta.
¹³ Faculty of Medicine, University of Alberta, Edmonton, Alberta.
¹⁴ Mazankowski Alberta Heart Institute, Edmonton, Alberta.
¹⁵ Critical Care and Cardiology, The Hospital for Sick Children, Toronto, Ontario.
¹⁶ Faculty of Medicine, University of Toronto, Toronto, Ontario.
¹⁷ Physiology & Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario.
¹⁸ Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, Toronto, Ontario.
¹⁹ Departments of Paediatrics and Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario.
²⁰ Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario.
²¹ Department of Paediatrics, University of Toronto, Toronto, Ontario.
²² Canadian Premature Babies Foundation, Sherwood Park, Alberta.
²³ Department of Medicine, University of Alberta, Edmonton, Alberta.
²⁴ G. F. MacDonald Centre for Lung Health, Covenant Health, Edmonton, Alberta.
²⁵ Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario.
²⁶ Division of Neonatology, Children's Hospital of Eastern Ontario and The Ottawa Hospital, Ottawa, Ontario.
²⁷ Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario.

Abstract

Bronchopulmonary dysplasia, the most common pulmonary complication of extremely preterm (EPT) birth, has longstanding multiorgan repercussions, with increasing reports of emphysema and cardiac disease in early adulthood. There are currently no clear recommendations pertaining to best practices for optimal multidisciplinary cardiorespiratory follow-up of EPT children. We report the outcomes of a 2-day consensus workshop involving a Canadian panel of 31 multidisciplinary experts with the goal of improvement and standardization of the cardiopulmonary follow-up care of EPT infants (i.e., born at <28 weeks' gestation), from neonatal discharge to mid childhood. The most relevant and important clinical outcomes to evaluate were identified. Practical aspects of integrating cardiopulmonary follow-up into ambulatory care clinics were explored. This article summarizes the discussions from this workshop and provides the panel's recommendations for clinical follow-up and research priorities.

Keywords: Bronchopulmonary dysplasia; Echocardiography; Exercise; Prematurity; Respiratory function tests..

Publication types

Review