MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling

Francesca Pagano; Federico Comoglio; Jacob Grinfeld; Juan Li; Anna Godfrey; Joanna Baxter; Yvonne Silber; Anthony R Green

doi:10.1038/s41375-018-0053-9

MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling

Leukemia. 2018 Aug;32(8):1826-1830. doi: 10.1038/s41375-018-0053-9. Epub 2018 Feb 27.

Authors

Francesca Pagano^{1

2}, Federico Comoglio^{1

2}, Jacob Grinfeld^{1

2

3}, Juan Li^{1

2}, Anna Godfrey³, Joanna Baxter⁴, Yvonne Silber^{1

2}, Anthony R Green^{5

6

7}

Affiliations

¹ Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.
² Department of Haematology, University of Cambridge, Cambridge, CB2 0XY, UK.
³ Department of Haematology, Cambridge University Hospitals NHS Foundation Trust Hills Road, Cambridge, CB2 0QQ, UK.
⁴ Cambridge Blood and Stem Cell Biobank, Department of Haematology, University of Cambridge, National Health Service Blood and Transplant Cambridge Centre, Cambridge, UK.
⁵ Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK. [email protected].
⁶ Department of Haematology, University of Cambridge, Cambridge, CB2 0XY, UK. [email protected].
⁷ Department of Haematology, Cambridge University Hospitals NHS Foundation Trust Hills Road, Cambridge, CB2 0QQ, UK. [email protected].

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism*
Gene Expression Regulation, Neoplastic*
Humans
Janus Kinase 2 / genetics
Janus Kinase 2 / metabolism*
Leukemia, Erythroblastic, Acute / genetics
Leukemia, Erythroblastic, Acute / metabolism
Leukemia, Erythroblastic, Acute / pathology*
MicroRNAs / genetics*
Mutation*
STAT5 Transcription Factor / genetics
STAT5 Transcription Factor / metabolism*
Signal Transduction
Tumor Cells, Cultured
Tumor Suppressor Proteins / genetics
Tumor Suppressor Proteins / metabolism*

Substances

Biomarkers, Tumor
MIRN101 microRNA, human
MicroRNAs
STAT5 Transcription Factor
STAT5A protein, human
Tumor Suppressor Proteins
JAK2 protein, human
Janus Kinase 2

Publication types

MeSH terms

Substances

Grants and funding